Collaborative agreements or memoranda of understandings have been established between UVI and:
- Antigua State College
- Case Western Reserve University/Frances Payne Bolton School of Nursing
- Clarence Fitzroy Bryant Community College
- College of Staten Island Center for International Service
- Columbia University
- Consortium for Caribbean Marine Studies
- Consortium of Caribbean Universities for Natural Resource Management
- Department of Commerce
- Dominica State College
- H. Lavity Stoutt Community College, British Virgin Islands
- National Oceanic and Atmospheric Administration
- Schneider Regional Medical Center School of Practical Nursing
- U.S. Department of the Interior
- Universidad Internacional (UNINTER), The Center for Linguistic and Multicultural Studies
- University Consortium of Small Island States (UCSIS)
- University of Cape Coast
- University of Florida
- University of Ghana, Legon
- University of Maryland - Eastern Shore
- University of Mississippi
- University of St. Maarten
- Virgin Islands Department of Labor School to Work/Career Division
- Virgin Islands National Park Service
- Sejong University, Philippines
- Adhikavi Nannayya University, India
- Buffalo State University of New York
- Fielding Graduate University
- Sri Krishnadevaraya University, India
- International Center for Studies in Creativity at Buffalo State- The State University of New York
- GITAM University, India
- Bharati Vidyapeeth University – Institute of Environment Education and Research, Pune, India
- GITAM School of International Business, GITAM University, India
- KL University, India
- University of Copenhagen, Denmark
- Bowie State University's Innovative Collaborative Center of Cybersecurity
- Yangzhou University
- Nantong University
- Xavier University
- University of Nebraska at Omaha
- South University-Savannah
- Virgin Islands Department of Education
- University of South Florida College of Engineering
- Study Caribbean, LLC
- Cooperative Center for Study Abroad at Western Kentucky University